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These symptoms typically emerge within the first week of initiation and peak around days 3-7, then gradually resolve as the body adapts to the medication

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Approximately one in six patients (up to ~16 %) experience localized reactions at the injection site

Improvements in libido, arousal, and satisfaction may lag 3 to 6 months behind the initial weight loss as the HPG axis recalibrates

Each location offers different advantages: your abdomen typically has more fatty tissue for consistent needle placement, your thigh is easier to reach and visualize, and your upper arm works well if you have someone assisting you