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Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span
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66,67 Most of the data on the use of acetyl-L-carnitine comes from small RCTs
As these sources decline, reduced glucose and insulin levels stimulates free fatty acids mobilisation from adipose tissue
In the liver, the rate of synthesis of selected proteins (i.e., albumin, transferrin, prealbumin, retinol-binding protein, and fibronectin) is decreased, whereas acute phase protein synthesis is accelerated [94]
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