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Whats more, the deficiency of GPX4 did not enhance the ER stress signal induced by H 2 O 2 , while in the absence of SELS, the lack of GPX4 would cause further deterioration of the ER stress signal

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In the present study, a decrease in sulfhydryl levels was observed in the hippocampus of the VPA group compared to the CT group, suggesting elevated oxidative stress in this region

Previous studies have demonstrated that rapamycin, an inhibitor of mTOR, reduces GPX4 protein expression and promotes ferroptosis and autophagy 9,10