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J.PruessnerJ.SousaN.AlmeidaO

These functional improvements often precede measurable changes in laboratory values

While immunotherapy has revolutionized cancer treatment, its efficacy in osteosarcoma remains severely limited by an immunologically cold and profoundly immunosuppressive tumor microenvironment (TME)

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differentiation balance, a genetic screen was performed that identified mutations that result in a synthetic tumorous phenotype in gld-2(null) mutants ( pas-5 (proteasome alpha subunit), which encodes an -subunit of the 20S proteasome ( pas-5 partial-loss-of-function allele revealed that it likely affected the Notch signaling pathway, as well as the GLD-1 pathway functioning downstream of GLP-1/Notch signaling ( g ene) was found to be one of these proliferation promoting proteins, and is targeted for degradation by the E3 ubiquitin ligase RFP-1 (ring finger protein) ( glp-1(gf) background, suggesting that there could be multiple targets whose regulated degradation is necessary for the proliferation vs differentiation decision to be properly maintained (Table 1)