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These agents bind within deep transmembrane pockets of the receptor, often exhibit stimulatory G protein alpha subunit (Gs)-biased signaling that can limit -arrestin-driven internalization, and are designed for food-independent, once-daily dosing
10.1007/s00404-017-4613-4 34 ChoiJ.JoM.LeeE.ChoiD
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SGLT2 Inhibitors in Combination Therapy: From Mechanisms to Clinical Considerations in Type 2 Diabetes Management
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