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PMC 5788147
You find it hard to lose weight because of low energy or a slow metabolism
MOTS-c is a short peptide (16 amino acids), which makes it relatively resistant to the enzymatic degradation that degrades larger peptides, but also means that reconstitution technique and storage conditions matter considerably
Research shows that the peptide activates a VEGF-independent pathway for nitric oxide production through Src kinase phosphorylation
It is not FDA-approved for weight loss: its clinical development was halted after Phase 2b, so any use is off-label and should be supervised by a licensed provider
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