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It's one of the reasons why if you've been on insulin for a long time, sometimes it can start to lose its efficacy because you literally are doing this loudspeaker effect where your cells become deaf to the signal

Achieving meaningful weight loss can feel overwhelming, especially when diets and routines dont deliver the results youre hoping for

doi: 10.1016/j.bioorg.2024.107851 138 FangZWeiLLvYWangTHamezahHSHanRet al

In clinical trials, semaglutide has demonstrated ~15% average body weight loss, while tirzepatide has shown results of up to 20%+ weight reduction in certain patient groups

Women and men who are overweight or obese can use it