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The decrease in BMI from these drugs will likely lead to a lower risk of obesity-associated cancers, including breast, colorectal, and endometrial cancer
Del Campo, J
10.34172/mejdd.2022.278 54 SchmidtH
Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications
Cardiovascular improvements can be dramatic and life-extending
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