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We then transfected the silenced cells and the control cells with plasmids for expression of the ARE-luc reporter gene and the ORF of KEAP1 (wt or point mutated in the identified sensor residues), which lacks its 3UTR sequence and is therefore resistant to the shRNA used (Fig
A role for glutathione as a glutamate reservoir may be a bridge between distinct lines of research that implicate glutamatergic dysfunction and aberrant glutathione levels in neuropsychiatric conditions such as schizophrenia
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