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Magnesium levels may increase when the eGFR falls below approximately 30 mL/min
Large CVOTs and other smaller studies have shown an association between the use of GLP-1RAs and DPP-4i on the relative rates of HF hospitalization
The UK medicines regulator, the MHRA, has updated the product information for healthcare professionals and patients regarding the "small risk of severe acute pancreatitis in patients taking GLP-1s." While rare, the sheer scale of GLP-1 use in the UK with one recent study suggesting 1.6 million adults had used them in the last 12 months, and 3.3 million were interested in trying them in the following year makes it important for clinicians and patients to be aware of the warning signs of pancreatitis, said the regulator
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