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The severity of cutaneous inflammation was scored 24 h after the last drug administration using the Psoriasis Area and Severity Index (PASI), scored by two scorers who were blind to the experimental groups: 0, none

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A recent study further illustrated that UA can directly suppress the release of inflammatory factors by inhibiting the HMGB1-TLR4-NF-B signaling in microglia in a mouse model of middle cerebral artery occlusion/reperfusion [187](Fig