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This bioavailability gap means oral dosing requires higher amounts to achieve equivalent systemic exposure
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Moreover, blocking the L-type VSCCs severely weakened the repression of H2AK119ub levels by BHBA, indicating that the BHBA-triggered activation of L-type VSCC-related calcium signaling resulted in the downregulation of H2AK119ub in hippocampal neurons (Figure 5D)
