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3 L of each sample was applied to the grid, pre-blotted for 10 sec, blotted for 34 s, and plunge frozen in a liquid ethane/propane mix at 180 C

Quick Answer: GLP-1 receptor agonists produce significant reductions in abdominal fat and waist circumference as part of generalized weight loss, though they do not selectively target belly fat

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From a therapeutic standpoint, pharmacological inhibition of SLFN4 either through small molecules like sildenafil or genetic approaches has demonstrated efficacy in preclinical models