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The reductions in lean mass do not necessarily indicate pathological muscle loss, as improvements in body composition, physical function, and quality of life have been reported with semaglutide and tirzepatide in subanalyses of the STEP-1 and SURMOUNT-1 programs [7,8]

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The recent introduction of dual-action medications, like tirzepatide (Mounjaro), which targets both GLP-1 and GIP receptors, shows promise in achieving even greater weight loss results compared to existing therapies

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