The estimated oral dose range from animal research is approximately 18 mg/kg, but human pharmacokinetic parameters including bioavailability fraction, Tmax, and clearance remain entirely unknown
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This highly pure, stable form has been clinically proven to survive the digestive tract in sufficient quantities to be transported across human intestinal epithelial cells and enter systemic circulation, effectively raising body stores of glutathione
It also forms when frying foods in oil at high temperatures.[ref] Reducing oxidative stress: In addition to their role in removing toxicants, the GST enzymes are also important for neutralizing reactive oxygen species (ROS) which cause oxidative stress in cells.[ref][ref] Genetic variants that decrease GST enzyme function increase the susceptibility to diseases that are caused by oxidative stress, such as neurodegenerative diseases, cancers, epilepsy, and ataxia.[ref] What happens when you have reduced GST function