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All four of these inhibitors reduce the reabsorption of filtered glucose, decrease the renal threshold for glucose, and promote urinary glucose excretion. Studies show that SGLT-2 use in diabetic kidney transplant recipients resulted in a decrease in hemoglobin A1C. There were potential side effects including increased infection risk and fluctuating allograft function
Why this matters and what to watch A few thoughts here: The regulatory risk is risingnot shrinking
10.3389/fnins.2019.01443 Front
Bessette also said that more real-world evidence is needed to study the safety and effectiveness of GLP-1[s] and GLP-1/[gastric inhibitory polypeptides] in these underrepresented and previously excluded populations to guide treatment decisions.
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