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Results suggest orforglipron leads to significant weight loss, at an average of 7.5% of body weight over 72 weeks for those on a 6mg dose, which increased to 8.4% with 12mg and 11.2% with 36mg, compared with 2.1% with placebo
If you reach a plateau or experience discomfort, the volume can be increased or decreased mid-treatment to optimize results
May 24 2024;doi:10.1056/NEJMoa2403347
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