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The stopping boundaries for this futility rule were to terminate enrollment on the trial if the number of overall responses compared to the number of patients enrolled who were evaluated did not meet the requirements of Supplementary Table S12
Weight-loss drugs in the glucagon-like peptide-1 (GLP-1) class, such as Wegovy and Mounjaro, are being analyzed for their impact not only on body weight but also on psychological changes that can influence human relationships
2 But as therapeutic use expands, so does our understanding of the complex physiological adaptations these drugs invoke
& Shulman, G
3.7 CB-839 affects oxygen consumption and cell proliferation, and induces apoptosis in combination with venetoclax, AZD-5991, but not ibrutinib in cell lines To improve the bioenergetic effects of glutaminase inhibition on the HG-3 and MEC-1 cell lines, CB-839 was tested in combination with CLL-specific drugs
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