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Mitochondrial glutamate is subsequently converted into alpha-ketoglutarate (-KG) by glutamate dehydrogenase 1 (GLUD1 or GDH1) or by several mitochondrial aminotransferases, including glutamic-pyruvic transaminase 2 (GPT2) and glutamic-oxaloacetic transaminase 2 (GOT2)

Another mechanism of action of BPC-157 is blocking the inhibitory growth factor called 4-hydroxynonenal, which is a negative modulator of growth