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found that tezepatide had a significant dose-dependent advantage in weight loss compared with placebo, GLP-1R agonists, and basal insulin (130)
Why this matters: Compounding means a pharmacy takes an active ingredient and mixes or combines it into a custommade medication for an individual patient
A study utilizing a national database found that individuals treated with GLP-1 receptor agonists had a significantly lower risk of developing glaucoma compared to those who were not on these medications
Results for the trial-product estimand were similar (Figure 2B)
The AACE/ACE obesity clinical practice guidelines recommend treating obesity as a chronic disease requiring long-term pharmacological management when lifestyle intervention alone is insufficient, and explicitly note that comorbidity burden should guide medication selection throughout the treatment course
