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More than half of glucagon-like peptide-1 receptor agonist (GLP-1 RA) users stopped utilization after only 1 year in a recent population-based study of semaglutide discontinuation in Denmark
GIPRs have been localized to human pancreatic -cells, and intravenous GIP infusion activates GIPR and intracellular signaling in pancreatic -cells, augmenting glucagonotropic effects in hypoglycemic conditions in humans (130)
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Do not restart a GLP-1 on your own after a suspected episode
However, the control group (i.e., individuals with obesity not on these medications to treat type-2 diabetes or weight loss) reported these assessments for the current time point only
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