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Moreover, LDs can actively participate in the biogenesis of autophagosomes from the ER (25, 92, 93)
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This results from fluid retention driven by GH's effect on sodium reabsorption and extracellular water expansion
Clinical trials show semaglutide (Wegovy) produces around 14.9% average body weight reduction, compared with approximately 35% for orlistat and 58% for naltrexone/bupropion (Mysimba)
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