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They physically disrupt the electron transport chain, the series of protein complexes inside the mitochondria that generate ATP, leading to a catastrophic drop in cellular energy production

Consequently, this leads to a faster reduction of its substrates but may also lead to an unspecific loss of electrons

In turn, the same haplotype in the Han Chinese ethnic group, constitutes a high-risk factor for the occurrence, with the use of allopurinol, of other reactions such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and DRESS syndrome.11 Thus, the same HLA alleles can cause different adverse reactions with the same medication, in different ethnicities, or with different medications, in the same population (Table 2)