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Before starting: GLP-1 drugs carry an FDA boxed warning for thyroid C-cell tumors observed in rodent studies

In a study at the University of Zurich with 23 patients with coronary artery disease, endothelial function was assessed by measuring the flow-mediated dilatation (FMD) of the brachial artery ( per day or placebo was supplemented in a RDP cross-over study for eight weeks

Kageyama K, Yamagata S, Akimoto K, Sugiyama A, Murasawa S, Suda T

It cannot establish a safe or effective human outcome

Typically, providers increase doses gradually about every four weeks until you reach the maximum level you can handle without significant side effects, like nausea