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The EMPA-REG OUTCOME trial detected slight elevations in nonfatal stroke events.11 In a subgroup analysis of the CANVAS trial, the results showed protective effects against haemorrhagic stroke, yet neutral effects on ischaemic stroke (HR 0.95
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Watanabe, Y
This Gs-biased profile may contribute to sustained receptor signaling with less desensitization, though the clinical implications of signaling bias in GLP-1 therapeutics remain an area of active investigation
BALANCE, however, needed insurers
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