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The practical effect is that prescriptions written for the reference product name do not automatically trigger biosimilar substitution in the way that a branded small-molecule drug triggers generic substitution
An automatic electronic vacuum pump was used to extract part of the air (the simulated altitude decompression speed of 2 m/s) in the cabin to simulate the plateau (altitude of 6000 m)
The seaglutide group lost 5.25kg of lean muscle mass (1.83kg in placebo), but this is initially not surprising given the larger overall weight loss in the treatment arm
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