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Realizing the potential of these multi-target agents will depend on sustained interdisciplinary collaboration to bridge laboratory findings and clinical applications

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This effort will require defining the exercise dose, modality, and temporal pattern that most effectively modulate exerkine profiles relevant to retinal health, as well as identifying the retinal cell types, endothelial cells, pericytes, Mller glia, or neurons, that directly respond to candidate exerkines in human-relevant systems