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Although they are a diverse group, DPP4i are all small, orally available molecules that interact with the catalytic site of DPP4 without disturbing any of its other known functions, including its effects on the immune system

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J Biol Chem 262:478485 Kato R, Hasegawa K, Hidaka Y, Kuramitsu S, Hoshino T (1997) Characterization of a thermostable DNA photolyase from an extremely thermophilic bacterium, Thermus thermophilus HB27

however, this is rare unless the primary tumor is extensive