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Taddei, M

"A signal is information on a new adverse event that is potentially caused by a medicine or a new aspect of a known adverse event that warrants further investigation." However, the EMA noted that the presence of a signal does not necessarily mean that a medicine caused the adverse event in question

The CCI is a weighted index that predicts the one-year mortality risk for patients with various comorbid conditions, assigning scores to different medical conditions and summing them to provide a total score that reflects the patients overall comorbidity burden

Applying techniques such as ChIP-chip, ChIP-Seq, ChIP-exo and CUT&RUN, and bioinformatics tools, the work of multiple groups has defined the genome-wide landscape of AR binding sites in CaP cell lines and tissues, which has allowed to more closely examine and characterize the corresponding DNA sequences [53]

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