Researchers looked at data from more than 430,000 patients aged 50 and older who took either a GLP-1, sodium-glucose cotransporter 2 inhibitors (SGLT2i), metformin or insulin to manage their diabetes for at least two years
Its wise to be cautious when introducing other potent actives
Higher GABA activity in the brainstem can reduce the sensitivity of the area postrema to nausea triggers, effectively raising the threshold for how much GLP-1 stimulation is needed before nausea occurs
For example, Rybelsus (semaglutide tablets), the first oral GLP-1 approved for type 2 diabetes, has demonstrated meaningful weight loss in clinical studies, although it currently requires strict administration guidelines (empty stomach, limited fluid intake before and after dosing)
It assists the pancreas in producing more insulin when blood sugar is elevated