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Without a spatially restricted and experimentally identifiable origin of ferroptotic stress, ordered patterns of cell death could simply reflect pre-existing gradients in ferroptosis susceptibility within heterogeneous microenvironments rather than true directional propagation
Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is a cytosolic PRR involved in innate immune inflammatory response during infection by viruses and bacteria and its hallmark function is to activate the NFB signaling pathway, which promotes expression and production of a proinflammatory cytokine network 14,15,16,17,18,19,20,21
Patients on chronic corticosteroids (asthma, autoimmune diseases) have impaired tissue healing, a well-known clinical problem
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