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En contraste, la activacin simultnea del GIPR estimula tambin la acumulacin de cAMP en tejidos adiposos y cerebrales, promoviendo tanto la oxidacin de sustratos energticos como la modulacin de las vas GABArgicas que regulan el apetito

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It found that in participants with overweight or obesity (body mass index (BMI) 27 kg/m 2 ), once-weekly injections of 5 mg, 10 mg or 15 mg of tirzepatide led to mean weight reductions of 15%, 19.5% and 20.9%, respectively, compared to placebo

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