It is usually introduced gradually to improve tolerability
Two 10-year case-control studies over very large samples of people with diabetes ( N = 360,205 and N = 73,869, respectively) equally observed no association between GLP-1RA use and incident depression 202,203
Results are slower than standard dosing, but the benefits of microdosing GLP-1 medications include better tolerability and higher adherence rates
The BRAT diet approach (bananas, rice, applesauce, toast) is often recommended, but it is terrible for protein intake
A smaller analysis, also published in JAMA Neurology, found that GLP-1 drugs as well as a similar class of diabetes medications known as SGLT2 inhibitors may have benefits for brain health with regard to Alzheimers disease and related dementias