Curiously the absolute need for vitamin B2 for vitamin B12 cycling appears to have been missed by the majority of authors and reviewers in the field (Zaric etal, 2019) Once overt vitamin B12 deficiency has been demonstrated in the neonate, in which serum vitamin B12 is lower than 250 pmol/liter, this should be addressed, either by injection of mixed Adenosyl/Methyl B12, or by topical application of teh mixed Adenosyl/methyl B12 oils
As such, it is involved in many biological processes, including the breakdown of fats, the reduction of serum cholesterol, serotonin activity modulation, gene expression, and insulin signal transduction
Studies testing doses up to 1 mg daily found no additional benefits above this threshold
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