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When the Hippo pathway is inactivated, activated YAP enters the nucleus, where it functions as a transcriptional coactivator of TEAD and enhances gene expression [121,122,123,124,125]
Marketing them for human use is unlawful
It is not indicated for type 1 diabetes or for diabetic ketoacidosis
In this study, long-term administration of rotenone in C57BL/6 mice triggered marked oxidative stress in the brain
We found that tirzepatide was ineffective at suppressing tumor growth in lean mice, suggesting resolution of underlying metabolic dysfunction (such as hyperleptinemia) is a predominant means through which tirzepatide protects against obesity-driven tumor growth
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