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Reference Garber, Cheng, Accurso, Adams, Buckelew and Kapphahn12,Reference Mehler, Yager and Solomon15Reference Norris, Harrison, Isserlin, Robinson, Feder and Sampson17 Hypoelectrolytic disorder with hypokalaemia, hyponatraemia, hypomagnesaemia and hypophosphataemia caused by dehydration or vomiting can lead to nephropathy and renal failure

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Phase 3 trials include a 4mg maintenance arm specifically because some individuals achieve excellent results at lower doses