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Formation of the DSF-copper (CuDSF) complex inhibits the chymotrypsin-like activity of the purified 20S or 26S proteasome in breast cancer cells (MDA-MB-231) (MCF10DCIS.com breast cells, but not in normal MCF-10A breast cells (Skrott et al., 2017

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and a different crystal form of the (partially) reduced enzyme (3.1 ), showing the physiological dimer and the entire C terminus of one subunit

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In fact, the same 2021 systematic review and analysis found that people routinely taking silymarin experienced a significant reduction in their fasting blood sugar levels and HbA1c, a measure of blood sugar control