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Osmotic laxatives such as macrogol (polyethylene glycol) are often considered first-line for chronic constipation on GLP-1 therapy, as they draw water into the bowel to soften stools
Variants in FTO , the fat-mass and obesity-associated gene, work with GLP1R , MC4R , and TCF7L2 to map the metabolic terrain any compound acts on
Further, inhibition of PDE3B inhibits insulin-induced glucose uptake and antilipolysis
However, GLP-1 also impacts several other mechanisms that contribute to weight loss
10.1016/j.jhazmat.2024.134394 J
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