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To be clear, studies suggest that GLP-1s generally lead to greater and faster weight loss results than relying solely on lifestyle changes like diet and exercise

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Quality and extent of evidence Key limitations and criticisms Balanced assessment For EPP, the evidence base is moderatetostrong: two highquality RCTs demonstrate clinically meaningful gains in sunlight tolerance and QoL, corroborated by prospective cohorts and PASS data with generally mild adverse events

**Increased Heart Rate**: Some individuals may experience an increase in heart rate or blood pressure, particularly if they consume high doses