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The evidence is pretty clear on this: a lot of patients regain weight when they come off GLP-1 therapy

Lancet Diabetes Endocrinol 13(6):482493 Stefanakis K, Kokkorakis M, Mantzoros CS (2024) The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation

Estimated concentration curves are mathematical estimates based on published pharmacokinetic half-life data they do not represent measured blood levels

The most popular GLP-1 medications include Ozempic, Wegovy, and Mounjaro

It is part of the medical decision