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For those stopping the newer, more effective drugs, such as semaglutide (Wegovy

Figure 12: Photograph Professor Vincent Marks (1930-2023), credit: Seaton)

The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke

However, some preclinical studies have also demonstrated that liraglutide inhibits proliferation and migration in breast cancer cell lines [33]

Semaglutide's mechanism involves slowing gastric emptying, enhancing glucose-dependent insulin secretion, and reducing appetite through central nervous system pathways