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In the UK, oral cyanocobalamin is the standard recommendation for dietary deficiency, whilst intramuscular hydroxocobalamin is preferred for pernicious anaemia or malabsorption
Enzyme selectivity for cleavage immediately C-terminal to proline or alanine residues at position 2 substrate peptides is dictated by the shape and size of the S1 pocket, which is lined by Val656, Tyr631, Tyr662, Trp659, Tyr666, and Val711 (Figure 6)
Megaloblastic anaemia a review from University Hospital, Kuala Lumpur
A 2019 IV infusion study confirmed 398% plasma elevation above baseline
(PubMed) Zhou J, Austin RC
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