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First, under normal conditions, elevated HO1 expression attenuates oxidative stress to exert cytoprotective effects, and second, sustained HO1 upregulation releases ferrous iron to exacerbate oxidative stress, which leads to ROS accumulation through the Fenton reaction
While not a cure, supplementation may help slow disease processes and improve quality of life
doi: 10.3390/ijms24032959
Enhanced insulin secretion : GIP and GLP-1 stimulate insulin release through partially distinct intracellular mechanisms
its ability to interfere with melanin synthesis
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