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Rheumatology 61 , 407412 (2021)

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The body breaks down peptides via proteolytic enzymes in the blood, liver, and kidneys meaning smaller peptides often have shorter half-lives

Learn about BPC-157 Oral (Stable Arginate Salt) Structures that resist this gauntlet share identifiable features: small size (dipeptides and tripeptides are absorbed via PepT1 transporter), cyclic scaffold that limits protease access, non-natural D-amino acid substitutions, or a fully non-peptide backbone (peptidomimetics)