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Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner (Meurot et al., 2022)

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Michael Hammond, a recent graduate of the internal medicine residency program at Northwesterns McGaw Medical Center

The challenges of achieving weight loss goals, and maintaining a healthy weight, are not unique to the GLP-1 phenomenon

She does note, however, that she did experience two unfortunate side effects of the drug: dryness and aching