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Brain (2011) 134(Pt 1):2109.10.1093/brain/awq273 45 GaroneCDonatiMASacchiniMGarcia-DiazBBrunoCCalvoSet alMitochondrial encephalomyopathy due to a novel mutation in ACAD9

Finally, setmelanotide can be used in older adults with monogenic obesity, caused by mutations in the leptin signalling pathway, although this is more commonly initiated in children and younger adults with severe and complex obesity [122]

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doi: 10.1074/jbc.RA117.001013 62 RodgersLCColeJRattiganKMBarrettMPKurianNMcInnesIBet al

Pregnant patients with B deficiency should be closely monitored and treated appropriately to ensure healthy outcomes