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It is widely accepted that alcohol use and a number of pharmacological agents, for example isoniazid, induce expression of CYP2E1 (see section Potential drug interactions with paracetamol metabolism and section Alcohol use)
Older/heavier users may need 0.4-0.5 mg
But today, the meaning of "nootropic" has expanded to include anything that affects the brain and its cognitive effects -- regardless of whether it is safe and effective
Rainey-Smith SR, Brown BM, Sohrabi HR, et al
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