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This indicates the peptides potential to address symptoms of cardiovascular and neurodegenerative diseases

doi: 10.1016/j.bbagen.2012.11.020 16

Use of CRISPR/Cas9-engineered INS-1 pancreatic cells to define the pharmacology of dual GIPR/GLP-1R agonists

As de novo synthesis of ceramide is located in the ER, which is absent in erythrocytes, it is thus assumed that erythrocytic ceramide should directly originate from the hydrolysis of sphingomyelin

Clinical translation would require trials in cardiac patient populations with appropriate safety monitoring given theoretical concerns about blood pressure effects and vascular remodeling