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Interestingly, we also show that kynurenine, a metabolite derived from tryptophan following inflammatory activation of IDO1 [46,47,48], is elevated in TTR-V30M patients but not in age-matched healthy controls

In This Article Dark Spots on Face: Causes, Treatments & Prevention You look in the mirror and notice it a patch of darker skin on your cheek, a brown spot near your temple, or stubborn marks left behind by old pimples

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