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The simultaneous activation of these G protein receptor signaling pathways on the islet cells may lead to additional antagonistic or synergistic interactions, but this is unknown
Important Note References
S.BrcicL.et al (2012)
Downstream genes of Nrf2 include NAD(P)H quinone oxidoreductase 1, HO-1, solute carrier family 7 membrane 11 (SLC7A11/xCT), NAD(P)H quinone oxidoreductase 1, thioredoxin 1, phase II detoxifying enzymes (e.g., GSH S-transferase, UDP-glucuronosyltransferase, GPX4, GSH reductase, and glutamate-cysteine ligase subunits
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